Found this on another site and thought it might be useful for everyone:
Untarget Defender
The Untarget Defender option is new to College Football 26 and is one of the best additions to football video games in a long time.
The Untarget Defender adjustment allows you to tell your offensive line to ignore a specific defender.
One of the most common blitzing tactics is for your opponent’s user defender (who everyone knows has no intention of actually blitzing) to hover right over an offensive lineman.
Even though you know it’s a bluff there was nothing you could do about it. Now just bring up your slide protection by pressing LB/L1 then click Y/Triangle, then select the defender you wish to “untarget.”
Once untargeted, the offensive line will not attempt to block that defender. If you know what you are doing, this can be very powerful. If you don’t, it may be best to stay away from this adjustment.
The best blocking tip I can leave you with though is to get into the habit of always resetting your slide protection to “Base” instead of empty.
This was on a site I came across called CollegeFootball.gg it’s got some useful stuff on so thought I’d share.
That last tip on base blocking is also a big one. And NEVER use empty blocking.